CYCLOSPORINS P21 - NEW FAMILY OF CLATHRATES
Michal Hušák1 ,Svetlana Pakhomova1, Alexandr Jegorov2 , Bohumil Kratochvíl1, Zdirad Zák 3, Ivana Císarová4, Ladislav Cvak2, Martin Buchta2
1 Department of Solid State Chemistry, Prague
University of Chemical Technology, Technická 5, 166 28
Prague 6, Czech Republic, e-mail:husakm@vscht.cz
2 Galena Co., Research Unit, Branišovská 31, 370
05 Ceské Budejovice, Czech Republic
3 Department of Inorganic Chemistry, Masaryk
University, Kotláoská 2, 611 37 Brno, Czech Republic
4 Department of Inorganic Chemistry, Charles
University, Albertov 6,128 43 Prague, Czech Republic
Keywords: Cyclosporin, Clathrates
Cyclosporins P21 are described as new class of clathrates. The crystal structure determination of the following structures is reported:
Cyclosporin A . dimethylisosorbide (ambient temperature) [1]
Cyclosporin A . tetrahydrofurane (ambient temperature)
Cyclosporin A . di-n-butylether (ambient temperature)
Cyclosporin A . di-n-butylether (ambient temperature)
Cyclosporin A . di-n-butylether ( 150K )
Cyclosporin E . acetone . water (ambient temperature) [2]
Cyclosporin E . 2-butanol ( 150K )
The shape of the cavity inside the structure of cyclosporin A . dimethylisosorbide is visualized on following picture.